Group items tagged

great article on sex hormones and neuroprotection.  This article summarizes the research on estrogen, progesterone, and aromatase activity in in vitro and in vivo studies.  Additionally, the study reviews the androgenic neuroprotection in men.  Who has said that hormones are not needed post menopausal again?  Maybe, that is the sign that they need the neuroprotective effect of hormones.

very good review of the differences in MS and hormones between the sexes.

progesterone shown to have neuroprotective effects in brain ischemic rat model.

progesterone shown to have neuroprotective and  healing properties in the CNS.  This has implications in Stroke, and possibly even excitotoxic disease such as Parkinson's, Alzhemier's...

This article briefly discusses the anti-inflammatory and neuroprotective effects of estriol (E3) and progesterone 

Good discussion and review of progesterone's role as neuroprotective in TBI.

Progesterone and allopregnanolone shown to have neuroprotective and neurogenesis properties in the brain. BDNF was positively correlated with progesterone. So as women age, progesterone falls, as progesterone falls, then BDNF falls and neuroplasticity declines and thus we see neurodegenerative disorders. And hormones are not needed? Who are these scientists that don't read research?!

rat model finds that progesterone effects internal cell enzyme activity.  In this case, progesterone increased PP2A in the cerebellum and in the hyippocampus.  Interesting, that E2 priming decreased the effects on the hippocampus, but not the cerebellum.  This reveals a biochemical link between sex hormones, progesterone in this case, and the brain.  Studies have shown progesterone to be neuroprotective in TBI.  This may be one mechanism.

Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.

progesterone shown to be neuroprotective in individuals with traumatic brain injuries.  In addition to improved neurologic function, there was a decreased mortality rate in the progesterone treated group compared to placebo.

Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease.  this study looked at a rat model.  The effect was not through inhibition of NF-kappaB, but through MAP kinase.

Estrogen is neuroprotective in postmenopausal women.

Very interesting article.  Early Progesterone treatment, in animal model, shown to improve neuropathic pain recovery.  This is by no means the first study to show this.  This has been shown numerous times in TBI, but the timing of therapy was the purpose of this article.  What is very interesting here is that the metabolites implicated here in the recovery are the same metabolites implicated in an increased tumor potential.